Semax
Semax is a synthetic heptapeptide analogue of ACTH(4–10), engineered with a Pro-Gly-Pro extension to enhance enzymatic stability and biological activity. In research models it modulates neurotrophic pathways (e.g., BDNF) and stress-response signaling, supporting studies in neuroprotection, synaptic plasticity, and cognition.
Batch Details: XA5-A1
Semax is a research-grade peptide derived from the adrenocorticotropic hormone fragment ACTH(4–10) with a C-terminal Pro-Gly-Pro extension to improve stability and receptor engagement. It has been studied for its ability to influence neurotrophic factor expression, neurotransmitter dynamics, and oxidative/inflammatory responses relevant to neural function and recovery.
Research SignificanceModulation of neurotrophic signaling (e.g., BDNF/TrkB) associated with synaptic plasticityNeuroprotection in models of oxidative stress, hypoxia/ischemia, and neuroinflammationCognitive endpoints, including learning, memory, attention, and executive functionRegulation of stress-axis and antioxidant pathways implicated in neuronal resilience
Potential Research ApplicationsNeuroplasticity and cognition paradigms (LTP, memory consolidation, attention)Models of ischemia/reperfusion injury and oxidative stressNeuroinflammatory pathway investigationsBehavioral neuroscience studies on stress adaptation and recovery
SpecificationsForm: Lyophilized peptide powderContent: Semax 5 mg per vialSequence: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)Storage: Store at −20 °C; once reconstituted, use promptly under sterile lab conditions
